Epilepsy
Epilepsy is a focal sensory system (neurological) jumble in which cerebrum movement becomes strange, causing seizures or times of uncommon conduct, sensations and now and then loss of mindfulness. Anyone can foster epilepsy. Epilepsy influences both males and females, all things considered, including ethnic foundations and ages.
Regarding the individual outcomes on the efficacy of monotherapy, the highest seizure
freedom rate at 6 months was with phenytoin (WA = 72%) while at 12-month
pregabalin (WA = 75%) and levetiracetam (WA = 74%) showed highest efficacy.
• Concerning ≥50% seizure reduction rates, levetiracetam showed highest efficacy at 6
and 12 months (WAs of 82% and 97%, respectively).
• However, treatment failure rates at 12 months were highest for phenytoin (WA = 34%)
and pregabalin (41%).
• When comparing the described polytherapy combinations with follow-up of ≥6
months, levetiracetam combined with phenytoin was most effective, followed by
levetiracetam combined with valproic acid.
Consult with our Best Seizures Doctor in Purnia
Safety and Tolerability of Lacosamide in Patients With Epilepsy
- As a third-generation antiseizure medication (ASM), lacosamide (LCM) is recommended worldwide for patients with
epilepsy. - The study aimed to provide more conclusive evidence for the safety and tolerability of LCM in patients with epilepsy.
- Eighty-three studies involving 12268 populations (11 randomized
clinical trials (RCTs), 16 cohort studies, 53 case series, and 3 case
reports) were included in our study.
– Meta-analysis of the total incidence of adverse events (AEs) of LCM was 38.7%
– Incidence of withdrawal due to AEs was 10.8% and incidence of serious adverse
events (SAEs) was 6.5%
– Most AEs were in the nervous system and digestive system.
– The most common AEs were sedation (15.8%), dizziness (15.7%), fatigue (9.4%), and
nausea/vomiting (9.3%).
– For children, the total incidence of AEs of LCM was 32.8% [95% CI (21.6%,
44.0%); n=16 studies], and the most common AEs were dizziness (8.6%),
nausea/vomiting (8.6%), and somnolence (6.8%).
Consult with Epilepsy Doctor in Purnea
Epilepsy Specialists in Purnea
Best Seizures Doctor in Purnia
What to do?
- Do call for crisis help when required.
- Do securely pad the individual’s head.
- Do shield the individual from any close by objects.
- Do time the length of the seizure.
- Do remain with the individual until they recuperate.
What not to do?
- Put nothing in the individual’s mouth.
- Try not to attempt to move the individual.
- Try not to attempt to control the individual.
Lacosamide is generally safe and well tolerated in patients with epilepsy. Common AEs were sedation,
dizziness, and fatigue